Publications

Amps K  et al, 2011, The International Stem Cell Initiative, Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage, Nat Biotechnol. 2011 Nov 27. doi: 10.1038/nbt.2051. [Epub ahead of print]

Andrews P, 2011, Discovering small molecules to control stem cell fate, Future Med. Chem. (2011) 3(12), 1539–1549

Yildirimman R et al, 2011, Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity, Toxicol Sci. 2011 Dec;124(2):278-90.

Nalos L et al, 2011, Comparison of I(Kr) blocking drugs Moxifloxacin and Dofetilide/E-4031 in 5 screening models of pro-arrhythmia reveals insufficient specificity of isolated cardiomyocytes, Br J Pharmacol. 2012 Jan;165(2):467-78. doi: 10.1111/j.1476-5381.2011.01558.x.

Sartipy P and Björquist P, 2011, Concise Review: Human Pluripotent Stem Cell Based Models for Cardiac- and Hepatic Toxicity Assessment, Stem Cells. 2011 March 23

Mandenius CF et al, 2011, Toward Preclinical Predictive Drug Testing for Metabolism and Hepatotoxicity by Using In Vitro Models Derived from Human Embryonic Stem Cells and Human Cell Lines — A
Report on the Vitrocellomics EU-project, ATLA 39, 1-25

Mandenius CF et al, 2011, Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review, J Appl Toxicol. 2011 Feb 16

Both SK et al, 2011, Differential bone-forming capacity of osteogenic cells from either embryonic stem cells or bone marrow-derived mesenchymal stem cells, J Tissue Eng Regen Med. 2011 Mar;5(3):180-90

de Peppo GM et al, 2010, Osteogenic potential of human mesenchymal stem cells and human embryonic stem cell-derived mesodermal progenitors: a tissue engineering perspective. Tissue Eng Part A. 2010 Nov;16(11):3413-26.

Andrews PD et al, 2010, High content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules, Biochem J. 2010 Oct 25;432

Synnergren J et al, 2010, Expression of microRNAs and their target mRNAs in human stem cell derived cardiomyocyte clusters and in heart tissue, Physiol Genomics, Sep 14 (Epub ahead of print)

Asp J, et al , 2010, Cardiomyocyte Clusters Derived from Human Embryonic Stem Cells Share Similarities with Human Heart Tissue. J Mol Cell Biol. 2010 Oct;2(5):276-83

Kane NM et al, 2010, Derivation of endothelial cells from human embryonic stem cells by directed differentiation: analysis of microRNA and angiogenesis in vitro and in vivo, Arterioscler Thromb Vasc Biol, 30:1389-97

de Peppo GM et al, 2010, Human embryonic mesodermal progenitors highly resemble human mesenchymal stem cells and display high potential for tissue engineering applications., Tissue Eng Part A. 2010 Jul

Bigdeli N et al, 2010, Superior osteogenic capacity of human embryonic stem cells adapted to matrix-free growth compared to human mesenchymal stem cells, Tissue Eng Part A. 2010 Nov;16(11):3427-40.

Andersson H et al, 2010, Assaying Cardiac Biomarkers for Toxicity Testing using Biosensing and Cardiomyocytes Derived from Human Embryonic Stem Cells. J Biotechnol. 2010 Oct 1;150(1):175-81

Englund MC et al, 2010, The establishment of 20 different human embryonic stem cell lines and subclones; a report on derivation, culture, characterisation and banking, In Vitro Cell Dev Biol Anim. 2010 Apr;46(3-4):217-30.

Jonsson MK et al, 2010, Quantified proarrhythmic potential of selected human embryonic stem cell-derived cardiomyocytes, Stem Cell Res, 4:189-200

Vidarsson H, Hyllner J and Sartipy P, 2010, Differentiation of human embryonic stem cells to cardiomyocytes for in vitro and in vivo applications, Stem Cell Rev, 6:108-20

Gerlach JC et al, 2010, Interwoven four-compartment capillary membrane technology for three-dimensional perfusion with decentralized mass exchange to scale up embryonic stem cell culture, Cells Tissues Organs, DOI: 10.1159/000291014

Brolén G et al, 2010, Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage, J Biotechnology, 145:284-294

Ellerström C, Hyllner J and Strehl R, 2010, Single cell enzymatic dissociation of human embryonic stem cells: a straightforward, robust, and standardized culture method, Methods Mol Biol, 584:121-34

Synnergren et al, 2009, Transcriptional profiling of human embryonic stem cells differentiating to definitive and primitive endoderm and further towards the hepatic lineage, Stem Cells and Development, DOI:10.1089/scd.2009.0220

Sartipy P et al, 2009, Regulation of 'stemness' and stem cell differentiation by microRNAs, IDrugs, 12:492-6

Emanuelsson K and Karlsson C etal, 2009, Human embryonic stem cell-derived mesenchymal progenitors-Potential in regenerative medicine., Stem Cell Res. 2009 May 19.

Bigdeli N et al, 2009, Coculture of human embryonic stem cells and human articular chondrocytes results in significantly altered phenotype and improved chondrogenic differentiation, Stem Cells, 27:1812-1821

Jonsson MKB et al, 2009, Improvement of cardiac efficacy and safety models in drug discovery by the use of stem cell derived cardiomyocytes, Expert Opinion on Drug Discovery, 4:357-372

Gerlach JC et al, 2009, 3D culture promotes spontaneous embryonic stem cell differentiation in vitro, Tissue Eng Part C Methods, Apr 21

Steel D, Hyllner J and Sartipy P, 2009, Cardiomyocytes derived from human embryonic stem cells - characteristics and utility for drug discovery, Curr Opin Drug Discov Devel, 12:133-40

Ellerström et al, 2009, Emerging technology platforms for stem cells, Human Embryonic Stem Cells in Drug Discovery, 417-437

Jensen J, Hyllner J and Bjorquist P, 2009, Human embryonic stem cell technologies and drug discovery, J Cell Physiol, 219:513-519

Thyagarajan B et al, 2008, Creation of engineered human embryonic stem cell lines using phiC31 Integrase, Stem Cells, 26:119–126

Mölne J et al, 2008, Blood group ABO antigen expression in human embryonic stem cells and in differentiated hepatocyte- and cardiomyocyte-like cells, Transplantation, 86:1407-1413

Sartipy P et al, 2008, Low molecular weight compounds for in vitro fate determination of human embryonic stem cells, Pharmacological Research, 58:152-158

Adler S et al, 2008, Testing potential developmental toxicants with a cytotoxicity assay based on human embryonic stem cells, Altern Lab Anim, 36:129-40

Synnergren J et al, 2008, Molecular signature of cardiomyocyte clusters derived from human embryonic stem cells, Stem Cells DOI:10.1634/stemcells.2007-1033

Bigdali N et al, 2008, Adaptation of human embryonic stem cells to feeder-free and matrix-free culture conditions directly on plastic surfaces, J Biotechnology, 133: 146-53

Bjorquist P et al, 2007, Human ES cells derived functional cells as tools in drug discovery, Drug Discovery World, Winter Edition 07/08

Ameen C et al, 2006, Human embryonic stem cells in drug discovery and cardiac regenerative medicine, Zeitschrift fur Regenerative Medizin, 2:26-29

Karlsson U, Hyllner J and Runeberg K, 2007, Trends in the human embryonic stem cell patent field, Recent Patents on Nanotechnology, 1:233-237

Sartipy P et al, 2007, The application of human embryonic stem cell technologies to drug discovery, Drug Discovery Today, 12:688-99

Meyer T et al, 2007, New cell models and assays in cardiac safety profiling, Expert Opin Drug Metab Toxicol, 3:507-17, Review

Améen C et al, 2007, Human embryonic stem cells: Current technologies and emerging industrial applications, Crit Rev Oncol Hematol, Aug 3.

Ek M et al, 2007, Expression of drug metabolizing enzymes in hepatocyte-like cells derived from human embryonic stem cells, Biochem Pharmacol, 74:496-503

Söderdahl T et al, 2007, Glutathione transferases in hepatocyte-like cells derived from human embryonic stem cells, Toxicol In Vitro, 21:929-37

Adewumi O et al, 2007, Characterization of human embryonic stem cell lines by the International Stem Cell Initiative, Nat. Biotechnol, 25:803-16

Ellerström C et al, 2007, Facilitated expansion of human embryonic stem cells by single cell enzymatic dissociation, Stem Cells, 25(7)

Synnergren J et al, 2007, Differentiating human embryonic stem cells express a unique housekeeping gene signature, Stem Cells, 25:473-80

Norström A et al, 2006, Molecular and pharmacological properties of human embryonic stem cell-derived cardiomyocytes, Exp Biol Med (Maywood), 231:1753-62

Sartipy P et al, 2006, Pluripotent human stem cells as novel tools in drug discovery and toxicity testing, IDrugs, 9:702-5

Ellerström C et al, 2006, Derivation of a xeno-free human embryonic stem cell line, Stem Cells, 24:2170-6

Caisander G et al, 2006, Chromosomal integrity maintained in five human embryonic stem cell lines after prolonged in vitro culturing, Chromosome Res, 14:131-7

Hanson C and Caisander G, 2005, Human embryonic stem cells and chromosome stability, Acta pathologica, microbiologica, et immunologica Scandinavica, 113:751-5.

Heins N et al, 2006, Clonal derivation and characterization of human embryonic stem cell lines, J Biotechnology, 122: 511-520

Brolén GK et al, 2005, Signals from the embryonic mouse pancreas induce differentiation of human embryonic stem cells into insulin-producing beta-cell-like cells, Diabetes, 54:2867-74

Maitra A et al, 2005, Genomic alterations in cultured human embryonic stem cells, Nat Genet, 37:1099-103

Sjögren-Jansson E et al, 2005, Large-scale propagation of four undifferentiated human embryonic stem cell lines in a feeder-free culture system, Dev Dyn, 233:1304-14

Darnfors C et al, 2005, High-resolution analysis of the subtelomeric regions of human embryonic stem cells, Stem Cells, 23:483-8

Noaksson K et al, 2005, Monitoring differentiation of human embryonic stem cells using real-time PCR, Stem Cells, 23:1460-7

Björquist P and Jeppsson A, 2004, Cell transplantation for myocardial regeneration: hype or reality?, Scand Cardiovasc J, 38:259-64

Sjögren A et al, 2004, Human blastocysts for the development of embryonic stem cells, Reprod Biomed, 9:326-9

Hansson M et al, 2004, Artifactual insulin release from differentiated embryonic stem cells, Diabetes, 53:2603-9

Heins N et al, 2004, Derivation, characterization, and differentiation of human embryonic stem cells, Stem Cells, 22:367-376